Most NAD+ products have no clinical evidence to support their marketing claims. At Nuchido, however, everything we do is supported by science, which is why we have conducted human clinical trials on Nuchido TIME+.
What Our Clinical Evidence Shows
Different from supplements that purely rely on testimonials, animal studies, or theories, Nuchido TIME+ is backed by human research.
Our evidence shows:
Increases in NAD+
Our clinical trial shows improvements in cellular NAD+ levels, helping the energy and repair systems that power our cells.
Improvements in Cellular Repair Pathways
Nuchido TIME+ activates the longevity protein SIRT1, which relies on NAD+ to function. Sirtuins are important in DNA repair, metabolic health, controlling inflammation, mitochondrial health, and activating autophagy.
Increased Energy Levels
Healthy mitochondria are vital for energy, stamina and cellular resilience. NAD+ is a critical part of the energy production process in the mitochondria and sirtuins activate mitochondrial repair pathways.
Improved Skin Health
After taking Nuchido TIME+, participants showed improvements in inflammation markers and skin clarity. This highlights the benefits of supporting skin health from within.
Enhanced Sleep Quality
Restoring your body’s NAD+ levels can improve the quality of sleep by regulating your circadian rhythm, the 24-hour cycle that your body follows to determine your sleep-wake cycles.
Reversal of Biological Age
Nuchido TIME+ increases cellular NAD+ levels, activating repair pathways and lowering inflammation to help restore youthful function and improve biological age.
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Read Our Clinical Trials
Click below to read the full research reports ofourclinical trials
Learn How Nuchido TIME+ Supports Biological Age Reversal
Nuchido TIME+ is proven to reverse biological age, meaning you really can age backwards from the inside
Scientific Papers
Our founder Dr Nichola Conlon is a longevity expert and has been researching NAD+ for many years.
Read her peer-reviewed papers on the science of NAD+ restoration.
FAQs Tied To Elements Of Our Clinical Evidence & Trials
How does Nuchido TIME+ help improve the body’s NAD+ levels?
- Nuchido TIME+ doesn’t contain any NAD+, because ‘pure’ NAD+ is unstable and not bioavailable. Instead, it works as an NAD+ activator, switching your body’s natural NAD+ production back on so you can make your own NAD+ just like you did when you were younger. Our multi‑ingredient formula goes further than other products, addressing the root causes of NAD+ decline rather than simply trying to top up levels.
- Read our detailed blog post about how every ingredient in Nuchido TIME+ works to discover why you should think of our supplement as an NAD+ activator.
How does NAD+ impact sleep?
- NAD+ and sirtuins work together to regulate your circadian rhythm, your body’s natural 24-hour internal clock. Throughout the day, NAD+ levels naturally fluctuate, helping keep your sleep, energy, and daily cycles in sync.
- With all of this in mind, we should be looking to keep our NAD+ at adequate levels as we age to reduce how much our sleep patterns change as we get older. Increasing your NAD+ levels can help ensure you get quality restorative sleep.
How does NAD+ reverse the body’s biological age?
- NAD+ supports the key processes that keep cells healthy, including cellular energy production and repair. Increasing NAD+ levels helps target the biological processes that drive cellular aging. By supporting cellular health, NAD+ can help improve your body’s biological age which is the rate at which your body is aging internally.
- Read our guide on how to reverse your biological age to learn more about this topic.
What are sirtuins?
- Sirtuins are cellular proteins that regulate various important processes including DNA repair, inflammation, metabolism, and autophagy (cellular cleanup). They rely on NAD+ to function, so as NAD+ levels decline with age, sirtuin activity drops too. This is a major contributor to cellular aging.