As scientists, we now understand why NAD+ declines with age, and we know how to fix these issues so that we can restore NAD+ levels.

NAD+ levels decline because there is:

  • A decrease in NAD+ production - youthful NAD+ production and recycling pathways get switched off during aging
  • An increase in NAD+ consumption - older cells consume and waste more NAD+

This combination leaves critical cellular health pathways without sufficient NAD+.

You need to restore NAD+ levels to support your cellular health.


In youthful cells, NAD+ is continuously used and recycled via the Salvage Pathway

Ensuring cells have an adequate supply of NAD+, so they can produce cellular energy and repair any damage

In older cells, NAD+ is wasted and cannot be recycled

This is largely due to the reduced expression of NAMPT, the enzyme that powers the Salvage Pathway

Increased expression of the inflamamtory molecule CD38 means less NAD+ is available for cellular health pathways

Collectively, the NAD+ deficit drives cellular aging

Nuchido TIME+ activates the NAD+ recycling pathway by activating NAMPT

Restoring the cell's natural ability to produce and recycle NAD+

Nuchido TIME+ also inhibits CD38 ensuring NAD+ is available for beneficial pathways

While the biology is complex, years of scientific research have established the precise steps in the NAD+ production pathway that must be fixed in order to miantain or increase NAD+ levels

Nuchido TIME+
is the result of this research, providing the cell with a combination of ingredients that have been proven to:
Increase the cell’s ability to make and recycle NAD+
Increase the raw, precursor material available to the cell for making NAD+
Reduce wastage of NAD+ so it can power cellular health pathways
By going beyond simple precursor ingredients, Nuchido TIME+ switches back on your cell's own NAD+ production pathways


Nuchido TIME+ addresses the causes of NAD+ decline, by re-activating the the Salvage Pathway, which is the main source of cellular NAD+
This whole-system approach goes beyond precursor supplements
Used in isolation precursor supplements can cause further dysfunction to the NAD+ network

Everything we do at Nuchido Laboratories is rooted in science. That is why we have conducted a human clinical trial with Nuchido TIME+ (which many supplements do not).

Click the button to view our clinical trial results.


A systems-approach to NAD+ restoration

(Biochemical Pharmacology)


A decline in NAD+ is a feature of aging and may play a causal role in the process. NAD+ plays a pivotal role in myriad processes important in cellular metabolism and is a cosubstrate for enzymes that play key roles in pathways that modify ageing. Thus, interventions that increase NAD+ may slow aspects of the ageing trajectory and there is great interest in pharmacological NAD+ restoration. Dietary supplementation with NAD+ precursors, particularly nicotinamide riboside, has increased NAD+ levels in several human intervention studies and arguably been the most robust approach to date. However, consistency and reliability of such approaches to increase NAD+, and also impact on markers of efficacy to slow or reverse features of aging, has been inconsistent. We argue that a major element of this variability may arise from the use of single-target approaches that do not consider the underlying biological complexity leading to NAD+ decline. Thus, a systems approach – targeting multiple key nodes in the NAD+ interactome – is likely to be more efficacious and reliable.

The Role of NAD+ in Regenerative Medicine

(Plastic and Reconstructive Surgery)


The understanding of the molecular and cellular basis of aging has grown exponentially over recent years, and it is now accepted within the scientific community that aging is a malleable process; just as it can be accelerated, it can also be slowed and even reversed. This has far-reaching implications for our attitude and approach toward aging, presenting the opportunity to enter a new era of cellular regenerative medicine to not only manage the external signs of aging but also to develop therapies that support the body to repair and restore itself back to a state of internal well-being. A wealth of evidence now demonstrates that a decline in cellular nicotinamide adenine dinucleotide (NAD+) is a feature of aging and may play a role in the process. NAD+ plays a pivotal role in cellular metabolism and is a co-substrate for enzymes that play key roles in pathways that modify aging. Thus, interventions that increase NAD+ may slow aspects of the aging trajectory, and there is great interest in methods for cellular NAD+ restoration. Given these recent advancements in understanding the cellular aging process, it is important that there is an integration between the basic scientists who are investigating the underlying mechanisms of cellular aging and the surgeons and aesthetic practitioners who are providing antiaging therapies. This will allow the effective translation of this vastly complex area of biology into clinical practice so that people can continue to not only stay looking younger for longer but also experience improved health and wellness.