How does Nuchido boost NAD+ when it doesn’t contain NAD+ or NMN?
If you look at the ingredients in Nuchido TIME+, you might wonder why our formulation doesn’t contain ‘pure’ NAD+ or NMN which are commonly found in other NAD+ supplements. The reason for this is simple – NAD+ is not bioavailable so it can’t be used in its ‘pure’ form and despite its popularity, the body struggles to efficiently convert NMN into NAD+.
This is why Nuchido TIME+ takes a unique approach to increasing NAD+. Rather than including ingredients because they are trendy, each ingredient in Nuchido TIME+ is specifically chosen to fix the multiple root causes of NAD+ decline. Think of Nuchido TIME+ as an NAD+ activator that restores your body’s natural capacity to make NAD+.
This blog will explain how the ingredients in Nuchido TIME+ work to increase NAD+ levels and restore cellular health.
How Nuchido TIME+ works to boost NAD+
Increasing NAD+ production
When you are young you naturally have high levels of NAD+ because your body makes all the NAD+ it needs using a cellular production pathway called the Salvage Pathway. You do not get NAD+ from food or external sources.
As NAD+ is used up for cellular repair and regeneration, it leaves behind a molecule called nicotinamide (NAM). This is an NAD+ precursor that the Salvage Pathway uses as a building block to make more NAD+ and replenish its stores. But as you age the main enzyme in this pathway (NAMPT) stops working causing a decline in NAD+ production.
Nuchido TIME+ contains Sophora Japonica Extract (containing quercetin and rutin) and Alpha Lipoic Acid which activate the NAMPT enzyme to restore youthful NAD+ production and recycling.
Reducing NAD+ demand
Another major cause of NAD+ decline is the increased demand for NAD+ during aging. This is because as you age, levels of chronic inflammation naturally build up in the body causing damage and wasting huge amounts of NAD+. This means it is important to lower chronic inflammation in the body not only to reduce NAD+ wastage, but also to ensure that new NAD+ generated is directed to beneficial cellular health pathways rather than inflammatory processes.
This is why Nuchido TIME+ contains Green Tea Extract (containing EGCG) and Parsley Leaf Extract (containing Apigenin) which are known to inhibit the inflammatory molecules which degrade NAD+. This means NAD+ can be directed towards beneficial pathways such as cellular repair and regeneration.
Providing a NAD+ precursor
The final part of the Nuchido formulation is the NAD+ precursor Nicotinamide (NAM). Whilst NMN has become a popular NAD+ precursor, it’s bioavailability is poor – it needs a special transporter to enter your cells which not all cells have. NAM on the other hand is freely bioavailable and is also the NAD+ precursor naturally preferred by the Salvage Pathway to make NAD+.
Combined with the ingredients above to activate the Salvage Pathway and reduce NAD+ demand, this additional NAM can be converted into fresh NAD+ and directed towards beneficial cellular health pathways.
Nuchido TIME+ is supported by clinical evidence
Nuchido TIME+ is the only product clinically proven in a human study to fix the root causes of NAD+ decline. Other NAD+ supplements containing NMN or ‘pure NAD+’ ignore these issues and as a result recent studies show that these products can cause inflammation and further cellular damage - exactly what you want to avoid.
In comparison, Nuchido TIME+ contains a combination of ingredients which work together to restore youthful NAD+ production and cellular function. We call this our whole-system approach. We appreciate this approach is unique which is why, unlike many other companies, we have invested in human clinical research to prove that our formulation works to:
- Increase cellular NAD+ levels
- Increase NAMPT to activate NAD+ production by the Salvage Pathway
- Lower inflammation, ensuring that NAD+ is being directed towards beneficial pathways
- Activate healthy aging proteins
- Lower biological age
- Increase energy levels
- Improve sleep quality
- Improve skin quality