How does Nuchido boost NAD+ when it doesn’t contain NAD+ or NMN?

When you are young you naturally have high levels of NAD+ because your body makes all the NAD+ it needs using a cellular production pathway called the Salvage Pathway. The NAD salvage pathway is the primary source of NAD+ within the body and is responsible for recycling NAD+ after it has been used by cellular processes. Maintaining the efficiency of this pathway is essential for healthy NAD+ production and long-term cellular function.  

As NAD+ is used up for cellular repair and regeneration, it leaves behind a molecule called nicotinamide (NAM). This is an NAD+ precursor that the Salvage Pathway uses as a building block to make more NAD+ and replenish its stores. But as you age the main enzyme in this pathway (NAMPT) stops working causing a decline in NAD+ production. 

Nuchido TIME+ contains Sophora Japonica Extract (containing quercetin and rutin) and R-Alpha Lipoic Acid which activate the NAMPT enzyme to restore youthful NAD+ production and recycling. 

Another major cause of NAD+ decline is the increased demand for NAD+ during aging. This is because as you age, levels of chronic inflammation naturally build up in the body causing damage and wasting huge amounts of NAD+. This means it is important to lower chronic inflammation in the body not only to reduce NAD+ wastage, but also to ensure that new NAD+ generated is directed to beneficial cellular health pathways rather than inflammatory processes. 

This is why Nuchido TIME+ contains Green Tea Extract (containing EGCG) and Parsley Leaf Extract (containing Apigenin) which are known to inhibit the inflammatory molecules which degrade NAD+. This means NAD+ can be directed towards beneficial pathways such as cellular repair and regeneration. 

The final part of the Nuchido formulation is the NAD+ precursor Nicotinamide (NAM). Whilst NMN has become a popular ingredient in many NAD+ supplements, its ability to reach and enter cells efficiently remains an area of ongoing research. NMN requires specialized transporter to enter your cells, whereas nicotinamide (NAM) can enter cells  freely and is the precursor naturally preferred by the Salvage Pathway to make NAD+. 

By combing NAM with ingredients that support NAD+ production and reduce NAD+ consumption, Nuchido TIME+ provides a more comprehensive approach to increasing NAD+ levels.  

Nuchido TIME+ is the only product clinically proven in a human study to fix the root causes of NAD+ decline. Other NAD+ supplements containing NMN or ‘pure NAD+’ do not directly target the underlying causes of NAD+ decline. As a result, they can cause further cellular dysfunction.  

In comparison, Nuchido TIME+ contains a combination of ingredients which work together to restore youthful NAD+ production and cellular function. We call this our whole-system approach. We appreciate this approach is unique which is why, unlike many other companies, we have invested in human clinical research to prove that our formulation works to: