Welcome to our blog The TIMES+ where we share NAD+ insights, product information and the latest scientific research on how to age well.

Swipe along to read some of our favourite blog posts.

Peter Diamandis: Longevity Routine

Peter Diamandis shares his personal longevity routine. From nutrition, to sleep, exercise and supplements (which include Nuchido TIME+) he shares what he is doing to extend his healthspan.

Top tips for taking your TIME+

If you are new to taking NAD+ supplements we wanted to provide you with our top tips to integrate Nuchido TIME+ into your day and answer some commonly asked questions.

Why we need dietary supplements

We often get asked - why do people need dietary supplements? Can’t we just get all the nutrients we need from our diet? In an ideal world the answer is yes - we would get everything we need to keep us functioning optimally from nature and our diet. However, this is becoming increasingly difficult.

How does GlycanAge meaure biological age?

One very exciting development in the longevity field is the creation of consumer tests that can measure your biological age. GlycanAge is a user-friendly test that provides valuable insight into how well your body is aging and evaluates which lifestyle habits are best for you.

Why Nuchido TIME+ does not contain NMN or NR

If you’ve heard of NAD+ supplements then you’ve probably heard of NAD+ precursor supplements such as NMN and NR. One of the most common questions we receive at Nuchido is why we don’t include these ingredients in our formulation and instead use nicotinamide (NAM).

Top 3 Longevity Misconceptions

With so much excitement surrounding longevity, we wanted to highlight three common misconceptions and what the latest research shows is the best way to support your health optimisation routine.

Hallmarks of Aging: An expanding Universe

The Hallmarks of aging are the cellular failures that longevity scientists agree ultimately drive the entire aging process. A recent publication now includes loss of autophagy, chronic inflammation and dysbiosis of the gut microbiome as three new hallmarks contributing to the aging process.

How to reverse your biological age

Unlike your chronological age, your biological age is very flexible, and studies show diet, physical activity, sleep, stress management and supplementation all contribute to a youthful biological age.

The science behind infrared saunas

Infrared saunas are very popular for their variety of benefits, but how do they work? Learn more about the science behind infrared saunas and how you can further enhance the benefits with NAD+ supplements.

Who can benefit from increased NAD+ levels?

With the increased conversation surrounding NAD+ supplements, we often get asked who needs to increase their NAD+ levels? This article will break down the latest research and explain which individuals may feel the greatest benefits from NAD+ supplements.

Boost your energy levels with red light therapy

One of the key signs of aging that we all experience is a loss of energy. How does a 7-year-old run around with never-ending energy, while adults struggle to keep up? Well, the answer lies in the mitochondria.

How is Nuchido TIME+ different from other NAD+ products?

NAD+ has gained a lot of well-deserved attention recently, but with so many products to choose from, it is important to understand what the latest scientific research shows.

Slow skin aging with NAD+

The skin is the largest organ in the body and the first to show the physical signs of aging. There are many treatments to slow the external signs of aging, however, it is important to look beyond the surface and address the root causes of skin aging at the cellular level. Learn how NAD+ can enhance skin health.

How to boost NAD+ levels

We often talk about the benefits of increasing your NAD+ levels, so what exactly can you do to support your cellular health and increase NAD+? Studies show NAD+ levels are heavily influenced by lifestyle factors, so there are variety of lifestyle practices that you can implement to boost your NAD+ levels.

NAD+ in Women's Health

Menopause is a key part of the aging process for women. While conversation around the menopause has increased, we want to extend the conversation to discuss the science behind the symptoms and how NAD+ supplements can support your clients who are experiencing menopause.

NAD+ in Functional Medicine

Functional medicine works to address the root cause of health problems, by not just looking at individual symptoms, but looking at the body as an entire network. At Nuchido laboratories we share this vision, using systems pharmacology we look at the root cause of why cellular aging occurs and how to fix it.

Why you need to boost your NAD+ levels

NAD+ is a hot topic in the world of health and wellness, loved by celebrities such as the Kardashians, Justin Bieber and Jennifer Aniston, it is the celebrity secret to slow aging. This article will explain why NAD+ supplements are essential for healthy aging and why we need to address aging at a cellular level.

Why we need to take a cellular approach to slow aging

To age well and feel our best we need to take an inside out approach. While we may see and feel the symptoms of aging externally, aging begins at a cellular level. Therefore, to truly have any impact on the aging process we must target the root causes at a cellular level, with NAD+ restoration.

What Nuchido TIME+ is doing in your cells

When taking Nuchido TIME+, our clinical trial has demonstrated the positive effects of the formulation at the cellular level, so that you can rest assured that Nuchido TIME+ is having a positive impact on your cellular health.

How Nuchido TIME+ works to boost NAD+ levels

There are several NAD+ supplements available, yet many fail to address the root causes of NAD+ decline. This article will examine why Nuchido TIME+ uses a whole-system approach to increase NAD+, our clinical trial data and the mechanism of action of our ingredients.

How to choose a supplement that works

Supplements can be a very valuable tool in optimising your health, but with so many supplements available it is important to choose those which will benefit your cellular health. These are our top tips for choosing an NAD+ supplement that actually works.

To supplement or not?

With many supplements on the market claiming to ‘reversing aging’ it can be hard to distinguish which are reputable. Dr Nichola Conlon and Nikolina Lauc discuss which supplements are clinically proven to reverse biological age.

NAD+ in Aesthetics 

We understand that keeping at the forefront of scientific research is essential to the value you deliver for your clients and to keep your business competitive. Learn why incorporating the NAD+ boosting supplement Nuchido TIME+ into your practice can benefit both your business and your clients.

Slow aging at a cellular level with Hyperbaric oxygen therapy

Recent studies have shown that hyperbaric oxygen therapy (HBOT) targets several of the 'Hallmarks of Aging' to improve cellular health. This article will detail how HBOT works to slow aging at a cellular level and how you can enhance the benefits with the NAD+ supplement Nuchido TIME+.

Rejuvenate your cells with Cryotherapy

Whole-body cryotherapy is a simple treatment that has a vast range of benefits. Learn more about the science behind cryotherapy and how to enhance the benefits with the NAD+ supplement Nuchido TIME+.

6 FAQs about Nuchido TIME+

At Nuchido we receive lots of amazing feedback and questions. In this article, we share the answers to the most common questions asked by our customers to support you in your journey when choosing an NAD+ supplement.

Proteins, Glycation and AGES

Proteins are essential for cell function and during aging they become damaged and stop functioning correctly. This article will look at glycation and how this damages proteins, why this drives cellular aging and what you can do to prevent this.

Sirtuins: The Longevity Proteins

This article will describe what sirtuins are, why they are linked with aging and how you can increase your sirtuin levels with lifestyle habits and the NAD+ supplement Nuchido TIME+

Inflammation and Aging
Inflammation is one of the Hallmarks of Aging. This article will explain what inflammation is, why it is involved in aging and how to reduce inflammation with lifestyle habits and the NAD+ supplement Nuchido TIME+.

Enhance the effect of NAD+ Infusions

We appreciate that NAD+ IV infusions are becoming increasingly popular as the benefits of NAD+ restoration become more widely recognised. However, there is now a way to prolong and enhance the positive effects of NAD+ IVs. This article will look at how to combine the NAD+ supplement Nuchido TIME+ with NAD+ IVs.

Meet Dr Nichola Conlon

Recently Nuchido CEO and Lead Scientist Dr Nichola Conlon sat down with Vanja Maganjić from GlycanAge to discuss her background, research into NAD supplements and why she founded Nuchido.

 NAD+ and the Hallmarks of Aging

Our previous article detailed the nine Hallmarks of Aging, how they impact cellular health, and contribute to the aging process. This article describes how increasing cellular NAD+ levels with NAD+ supplements can positively impact all the Hallmarks of Aging and subsequently slow biological aging.

Healthy Habits for 2023

Adopting healthier habits in 2023 can help you feel your best now and keep you feeling fantastic as you get older. We wanted to share our top tips for improving your healthspan in 2023 and how NAD+ supplements can help you achieve your goals.

What are the Hallmarks of Aging?

Aging is not a singular process but rather a complex web of cellular dysfunction. The key cellular changes which underpin systemic age-related decline are termed the ‘Hallmarks of Aging’ and these processes together drive cellular dysfunction and aging. Read the article to learn more about each of the Hallmarks of Aging.



Lifestyle habits that decrease your NAD+ levels

NAD+ levels decline by around 50% every 20 years, but lifestyle factors also impact NAD+ levels. This article will look at how lifestyle influences cellular NAD+ and how to increase NAD+ levels with the support of NAD+ supplements.

The Role of NAD+ in Regenerative Medicine

The October issue of the Journal of Plastic and Reconstructive Surgery features an exciting new paper from Nuchido CEO and Chief Scientist Dr Nichola Conlon. Discussing the role of NAD+ in targeting the Hallmarks of Aging, how this benefits cellular health and also the surface level in the skin.


Why you should measure your biological age

It may shock you to learn that you have more than one age. Your chronological age and your biological age. This article will look at what your biological age is and why knowing this information can be very beneficial.


Support your mitochondria with NAD+

Mitochondrial dysfunction is a key hallmark of aging. Learn why mitochondria are essential for cellular function, the link between mitochondrial function and aging, and how NAD+ supplements can support mitochondrial health.

What is NAD+ and how to boost it?

While we cannot stop time, studies show that we do have more control over how we age than once thought and multiple lifestyle practices have now been identified which can help keep you, younger for longer. Increasing levels of the cellular molecule NAD+ is vital for aging well.

Fighting Fatigue with NAD+

One of the symptoms of the peri- and menopause that is well established is fatigue. Learn more about the role of estrogen in energy production and how you can combat this fatigue with NAD+.

Feel Better After 40 with NAD+

As we get older, we notice changes in our bodies and can often feel things don’t function the way they once did. This can include decreased energy, brain fog and trouble getting a good night’s sleep. You may have wondered what you can do to mitigate these physical signs of aging, and the answer may lie in NAD+.

Menopause, Biological Age and NAD+

Is the menopause making you age faster? The latest scientific research now shows that this is true, with menopause being shown to increase biological age – the rate at which your cells are aging inside.

Intermittent Fasting, AMPK and NAD+

Intermittent fasting has a variety of health benefits, many of which are attributed to the increase in NAD+ levels caused by fasting. Learn more about the pathways activated by fasting and how to combine NAD+ supplements with your fasting routine to maximise the benefits.

How to optimise your circadian rhythm

Your circadian rhythm is your internal timetable found in every cell and organ in your body. It helps to regulate behaviour, physiology, metabolism and cell function - including NAD+ production. Therefore, ensuring you have a robust circadian rhythm is vital to aging well.

NAD+: The healthy aging molecule

NAD+ has been hailed as the 'fountain of youth' and is considered one of the most important molecules for healthy aging. But what exactly is NAD+ and why is it linked to the cellular aging process?

Sirtuins, NAD+ and Aging

Sirtuins are described as 'guardians of the genome' but why are they so important to aging well? This article will describe what sirtuins are, how they are linked to NAD+ and why Prof David Sinclair views sirtuins as a key pathway in aging biology.

The Longevity Genes that slow aging according to David Sinclair

Research has identified many different genes and cellular pathways that are associated with aging, but Professor David Sinclair believes there are three key biological pathways which are vital to regulating our cells and if we can control them, we can slow the aging process.

Why we age according to David Sinclair

Read more about David Sinclair's Information Theory of Aging as described in his book Lifespan: Why we age - and why we don't have to, and his podcast of the same name.

David Sinclair on NAD+

Professor David Sinclair author of Lifespan: Why we age and why we don’t have to, and recently released podcast by the same name is a pioneer in the longevity field. Learn about David Sinclair's views on NAD+ and Sirtuins and why he considers them longevity genes.

5 reasons you need more NAD+

If you want to continue performing at your peak, then you will be interested in increasing your NAD+ levels. That is because NAD+ is vital for cellular health. This article will describe 5 of the key cellular functions which rely on NAD+ and how you can increase your NAD+ levels.

Increase energy levels with NAD+ supplements

Aging is associated with declining energy levels, which is linked to declining NAD+ levels. Learn how Nuchido TIME+ can increase NAD+ and energy levels.

Next Generation NAD+ Supplements

There are many NAD+ boosting supplements available but the latest research shows that a whole system approach is needed to address the root causes of NAD+ decline. Nuchido TIME+ goes beyond just precursor supplements to target each component of the NAD+ network which becomes altered with age.

Understanding Cellular Aging

Key changes occur within our cells which drive the cellular aging process, and contribute to the signs of aging we see and feel. This article discusses what aging is according to science and how we can slow aging at a cellular level.

The Introduction of Cellular Health to Aesthetics

While aesthetics has previously focused on using topical products and treatments to reduce the signs of ageing, a shift has occurred, with more treatments focusing on slowing ageing at the cellular level.

A Systems Approach To NAD+ Restoration

Nuchido CEO and Chief Scientist Dr Nichola Conlon recently published a review article in the Journal of Biochemical Pharmacology. The article discusses why NAD+ is critical to healthy aging and the best approach to boost NAD+ levels. Read a summary of the paper here.

Welcome to the World of Anti-Ageing Science

When it comes to ageing well, there have been some serious developments in the world of academic research over the last ten years that could have significant implications on enhancing the advice and services offered by professionals.

NAD+ for Professionals

As a professional who wants to keep up with the latest science and innovation and pass that knowledge along to your clients, you need to become familiar with NAD+, the latest breakthrough in longevity science.

Maximizing the Health Benefits

The final aspect of the Nuchido TIME+ formulation is designed to maximize the overall health benefits. That is why Nuchido TIME+ contains black pepper extract, vitamin C and zinc.

Increasing NAD+ Precursor Ingredients

Once the NAD+ production pathways have been restored and the waste of NAD+ has been limited, then adding in additional raw materials that the cell can use to manufacture NAD+ can be considered.

Reducing Consumption and Excretion of NAD+
The greater our understanding of age-related NAD+ decline the more it is becoming apparent that pumping more precursors (raw material) into the cell isn’t enough to fix the underlying problem. NAD+ declines not only because of a decrease in NAD+ production but also a huge increase in NAD+ consumption.

Enhancing the Salvage Pathway with Nuchido TIME+

For an NAD+ supplement to address the fundamental causes of NAD+ decline, it needs to act on the cell’s ability to make and recycle NAD+ and the primary source of this is via the salvage pathway.

Why NAD+ Declines with Age
We talk a lot about the importance of NAD+ and why it is so valuable to maintain your NAD+ levels as you age to retain your active and healthy lifestyle. In order to appreciate how Nuchido TIME+ works it is important to understand what happens to NAD+ levels as we age and what is occurring inside our cells.
Father of Biohacking hails Nuchido's NAD+ product as "Groundbreaking"

Dr Nichola Conlon, founder of Nuchido Laboratories, which creates scientifically backed products to promote healthspan features on Bulletproof Radio. She discusses the role of NAD+ in aging and Nuchido's breakthrough NAD+ booster with US author, entrepreneur and father of bio-hacking Dave Asprey.

Dave Asprey: Biohacking NAD+ with Nuchido TIME+
Dave Asprey – author, founder of BulletProof Coffee and all-round father of biohacking – interviewed Nuchido founder Dr Nichola Conlon on his #1 biohacking podcast, BulletProof Radio. They discuss the role of NAD+ and NAD+ supplement Nuchido TIME+ in taking control of the aging process and optimizing health.
What are NAD precursors?
If you're interested in increasing your NAD+ levels, you may have started researching various NAD+ supplements only to be met with a host of information about "precursors". Here, we break down exactly what an NAD+ precursor to help you navigate your NAD+ boosting needs.
How to read a supplement label?
Labels can be confusing. Have you ever found yourself unsure of certain ingredients? Or questioning if a supplement is of good quality? Cut through the hype and jargon with our expert cheat sheet on how to best understand your supplement labels.
What does Nuchido mean?

Nuchido (pronounced noo-chee-do) means “Path to Long Life” in Japanese, however, there is even more meaning behind our one-of-a-kind name, which traces all the way back to the Japanese village, Ogimi. Here we share the Nuchido story.