NAD+ has gained a lot of well-deserved attention recently, but with so many different products to choose from, it can be hard to know which one is best for you.  Not all supplements are created equally, so this article will look at why NAD+ declines during aging, how the Nuchido TIME+ formulation works and how we are different from other products such as NMN NAD+ supplements, IVs, patches and injections.

Why does NAD+ decline?

First of all, let’s break down why NAD+ declines as you age. In simple terms, it’s a supply and demand issue.  As you get older NAD+ production declines whilst the demand for NAD+ increases, leaving your cells without enough NAD+ for critical cellular processes which drives the aging process.

Decreased NAD+ Production 

• Your body naturally makes all the NAD+ it needs - you don't get any NAD+ from your diet. Your cells have an NAD+ production pathway called the Salvage Pathway which makes and recycles NAD+.
• In youthful cells, NAD+ is continuously produced when it is recycled and restored by this pathway. But during aging NAD+ declines because the main enzyme in this pathway (NAMPT) stops working.

Increased NAD+ Demand

• At the same time, older cells also have more damage and inflammation so the demand for NAD+ increases. One of the key hallmarks of aging is ‘inflammaging’. This occurs when the immune system creates inflammation even when it isn’t needed, leading to ‘chronic inflammation’.
• Chronic inflammation is known to deplete NAD+ levels and is damaging to your body .  For example, in the skin inflammation degrades collagen and in the brain inflammation contributes to brain fog.

This increased demand and reduced production causes NAD+ to rapidly decline as you get older. Nuchido TIME+ is the only product that is proven in human clinical trials to fix these root causes of NAD+ decline, restoring youthful NAD+ production and demand in the cells.

How do other NAD+ products work?

Oral NAD+ capsules

Many companies sell 'pure' NAD+ in oral capsules but NAD+ is very unstable and is degraded in the gut. You don't get any NAD+ from external sources or your diet - your cells have an internal production pathway to make NAD+ directly where it is needed.

NAD+ Injections, patches and IVs

NAD+ injections and NAD IV infusions get NAD+ into the blood - but not into the cells where it has its beneficial effect. This is because NAD+ is a large molecule meaning that it struggles to cross the cell membrane and remains stuck in the blood.

Clinical studies on NAD+ IV infusions are extremely limited and show that infused NAD+ is broken down and removed from the body.  Recent data also shows that NAD+ IV infusions trigger an inflammatory reaction because such large amounts of NAD+ are not naturally found in the blood, so the body has to work hard to remove it. This helps to explain why people experience unpleasant side effects during NAD+ infusions such as nausea and chest tightness.

Despite their rise in popularity, there is no clinical evidence to show that NAD+ injections or patches are safe or effective.

Precursor supplements - NMN and NR

Precursor supplements such as NMN and NR are the raw materials that your cells use to make NAD+. But the latest science shows that as you get older your body struggles to convert these raw materials into NAD+. This is because the main enzyme that powers this reaction (NAMPT) declines with age.  So taking NAD+ precursors alone is similar to supplying a factory with raw materials even though you know the machines are broken. They ignore the root cause of the problem.

Because of this, precursor supplements can also cause methyl donor depletion and inadvertently drive inflammation because they put further stress on the NAD+ pathway in your cells. This is why it is commonly recommended to take other supplements such as TMG (trimethylglycine) alongside NMN to counteract these effects – but taking one supplement to fix the side effects of another is not best practice.

Nuchido TIME+ restores youthful NAD+ production

Unlike other NAD+ boosting methods, Nuchido TIME+ is clinically proven to restore the body's natural NAD+ production pathway - it is a next generation NAD+ booster. Our unique formulation does not contain NAD+ or NMN – instead it contains a combination of ingredients that work to fix the root causes of NAD+ decline. The ingredients in Nuchido TIME+ work by:

• Increasing NAD+ production – activating NAD+ recycling in your cells by increasing levels of the NAD+ recycling enzyme – NAMPT
• Reducing NAD+ demand - reducing inflammatory processes that waste NAD+, ensuring NAD+ is available for beneficial pathways
• Supplying the NAD+ precursor nicotinamide which can now be converted into NAD+

Nuchido TIME+ is also supported by several human clinical trials which show that Nuchido TIME+ boosts cellular NAD+, activates NAMPT and lowers inflammation, which resulted in a reversal of biological age. This translates to whole-body benefits including increased energy levels, enhanced sleep quality and improvements in skin health.

For a summary of how Nuchido compares to other NAD+ products read our summary table below.