This is a very common question we get asked at Nuchido. Within the longevity industry the most popular NAD boosting strategy incorporates NAD+ precursor supplements. NAD+ precursors are the raw material that the body uses to make NAD+.
Here at Nuchido we take a different approach to boosting NAD+ levels. We appreciate that NAD+ decline as we age is a multi-faceted issue that cannot just be fixed by one substance. With a background in systems pharmacology our scientists have worked for many years studying the best possible formulations to provide long term sustainable benefits. In order to understand how our product differs from a simple precursor we must appreciate what actually occurs to our cellular NAD+ levels as we age.
NAD+ decline is highly complex
In older cells there is more DNA and cellular damage, more inflammation and therefore older cells require higher levels of repair. Consequently, older cells use more NAD+ and are producing more waste nicotinamide (NAM). In addition to this, the efficiency of the salvage pathway which is responsible for recycling waste NAM back into fresh NAD+ declines with age. This is due to declining levels of the NAMPT enzyme which powers this process.
Overall, as we age our cells use more NAD+ than they can make or recycle. Therefore, all the repair and maintenance pathways within the cell are fighting over the dwindling supply of NAD+. This leads to many of the signs of ageing such as energy loss and increased recovery time.
Key Points to remember
- The salvage pathway is the largest producer of NAD+, via recycling waste nicotinamide (NAM) within the cell.
- NAM is, therefore, the preferred precursor of the cell, and the salvage pathway the preferred production pathway.
- NAD+ is a large molecule which cannot cross the cell membrane, so it must be made inside of the cell.
The Lone Precursor
Now we understand what happens within the cell as we age, lets analyse how NAD+ precursors work. Precursor supplements work by shipping more of the raw material (precursors) into the cells which it uses to make NAD+.
This can cause a temporary increase in NAD+ levels ~60%. However, the increase in NAD+ is limited, as it doesn’t address the underlying reasons why NAD+ declines. The deficit in NAD+ is not because of a lack of precursor raw material. It is because the cells are using more NAD+ and are unable to recycle the breakdown products. Which brings us back to the salvage pathway.
Nuchido Time+ uses a whole-system approach
At Nuchido we understand this biological complexity and address it using a systems pharmacology approach. By just targeting one aspect of the NAD+ pathway the cell will find a way to work around this making any intervention you do useless (referred to as redundancy). Therefore, we don’t just provide the cell with raw material by using a precursor, instead we combine a variety of ingredients that fix the underlying problems in the cell to create a greater increase in NAD+ levels.
- Boosts levels of the NAMPT enzyme to enhance activity of the salvage pathway, enabling NAM to be recycled back into fresh NAD+
- Inhibits enzymes such as CD38 which use up and waste lots of NAD+
- Inhibits NMNT and NAM methylation to prevent removal of NAD+ precursors from the cell and promotes their recycling back into fresh NAD+
By using this whole-system approach to fix the damaged parts of the cell, we can restore the cells ability to make and recycle NAD+, prevent NAD+ wastage and also provide the cell with the raw material precursor it needs to give the ultimate cellular NAD+ boost.
Our pilot study conducted in two individuals showed a 242% increase in NAD+ levels, with Nuchido TIME+. We are very confident in our science and are awaiting the results of our 28-person double blind clinical trial.
We hope it is now clear why NAD+ boosting strategies should not just be limited to NAD precursors. A greater NAD+ boost can be obtained with a multi-target approach the tackles the root of the problem.