With so many NAD+ products available it can be difficult to know which will work best for you. Read our blog below to learn more about our unique approach to NAD+ restoration and why Nuchido TIME+ is the next generation NAD+ boosting supplement.
You can increase your NAD+ levels naturally with exercise and fasting practices, but many people also use NAD+ supplements to further optimize their levels. It is important to note that NAD+ is a large molecule, so pure NAD+ struggles to enter many cells. That is why cells have their own efficient way of making NAD+ inside the cell.
Youthful cells make NAD+ via the Salvage Pathway
To understand the best method to increase your NAD+ levels, the first thing to appreciate is how youthful cells naturally make NAD+. NAD+ is a large molecule so we do not absorb whole NAD+ from food our outside sources, instead our cells have their own NAD+ production pathways that keep our bodies supplied with all the NAD+ we need.
As NAD+ is a big molecule your cells prefer to recycle it rather than make it entirely from scratch. This NAD+ recycling system is called the Salvage Pathway and is the largest source of NAD+ in youthful cells.
When the NAD+ is used up in energy production and by cellular repair pathways it leaves behind the waste product nicotinamide (NAM). This nicotinamide is then recycled back into fresh NAD+ that can be used again by the cells.
This means that when we are young, our NAD+ levels are high because our cells can make and recycle all the NAD+ they need.
NAD+ production declines during aging
As we get older NAD+ levels decline, by around 50% every 20 years and this is due to the loss of this natural NAD+ recycling ability within cells. It is now known that levels of the enzyme which powers the Salvage Pathway (NAMPT) declines with age, meaning less NAD+ recycling.
When this happens the waste nicotinamide accumulates in the cell as it cannot be recycled. Cells work optimally when there is ‘homeostasis’ (when everything is in balance) so they have to methylate and remove the excess nicotinamide from the cell.
Alongside this decline in NAD+ recycling, there is also an increased demand for NAD+ in older cells due to increased levels of inflammatory CD38 and DNA-repairing PARPs. Collectively, this decline in NAD+ production and increase in consumption create an NAD+ deficit within the cells.
Nuchido TIME+ restores youthful NAD+ production
Nuchido TIME+ is the next generation NAD+ supplement because it is the only product proven in human clinical trials to address these root causes of NAD+ decline and restore your cells natural ability to make NAD+.
The Nuchido TIME+ formulation works to:
Increase NAD+ production:
- Nuchido TIME+ contains Quercetin and Rutin for their ability to activate NAMPT (the enzyme which powers the Salvage Pathway). Allowing the cell to recycle NAD+ in the same way youthful cell's do.
- R-Alpha Lipoic Acid (R-ALA) is also included as it activates AMPK. This is the pathway activated by exercise and fasting – which are known to increase NAD+. ALA mimics this and AMPK further activates the NAMPT enzyme to promote NAD+ recycling.
Inhibit inflammation and lower NAD+ demand :
- Nuchido TIME+ apigenin from parsley leaf, which inhibits the activation of the inflammatory molecule CD38. The expression of CD38 increases with age as levels of chronic inflammation increase and is one of the main consumers of NAD+.
- Green tea leaf extract contains EGCG for its ability to inhibit NNMT. This enzyme powers the pathway that removes nicotinamide (NAM) from the cell. Now the Salvage pathway has been restored NAM can be recycled back into fresh NAD+, so its removal is inhibited.
Provide an NAD+ precursor:
- As the salvage pathway has been restored we also include nicotinamide (NAM) in our formulation, as our NAD+ precursor to further boost NAD+ levels.
- We use NAM rather than NMN or NR because it has better absorption, it doesn't need a transporter to enter cells.
We call this our whole-systems approach to boosting NAD+. It goes beyond just supplying the cells with precursor materials and instead addresses the root causes of NAD+ decline. Our clinical trials showed that Nuchido TIME+ increased NAD+ levels, activated sirtuins, reduced inflammation and reversed biological age. Nuchido also has whole body benefits including increased energy, improved sleep quality and improvements in skin health.
The latest scientific research has shown that the loss of NAD+ recycling combined with increased consumption of NAD+ is the root cause of NAD+ decline. Therefore, when looking to increase your NAD+ levels be sure to use supplements that target each of these components.