How Nuchido TIME+ reverses aging

When you think of anti-aging products you may think of face creams and collagen supplements, however these products merely work to fix the consequences of aging. They fail to address the reasons why aging is occurring in the first place. There is now a new generation of products, supported by scientific evidence, which go beyond the surface to address the root causes of aging at the cellular level.

NAD+ supplements have emerged as a new approach to healthy aging by restoring your cellular health. Read the article below to learn how the next generation NAD+ booster, Nuchido TIME+, works to reverse aging.

 

Nuchido TIME+ boosts NAD+ and sirtuins

The Nuchido TIME+ formulation is designed and clinically proven to boost cellular levels of NAD+ and sirtuins.  NAD+ and sirtuins work together to promote cellular health. NAD+ is an anti-aging molecule naturally found in every cell, whilst the sirtuins are a family of seven proteins – often referred to as longevity proteins – that perform critical cellular functions.

NAD+ and the sirtuins work together to promote cellular health. This is because NAD+ acts as a fuel to drive the activity of the sirtuins – without NAD+ they cannot function. This means that as NAD+ levels decline during aging so does sirtuin activity.

The key functions of NAD+ and sirtuins include:

  • Cellular repair and rejuvenation
  • Cellular energy production

Therefore, when NAD+ and sirtuin activity declines, cellular damage accumulates in cells and tissues, preventing them from functioning properly, driving the aging process. This is felt as fatigue, brain fog, sleep disruptions, loss of skin elasticity and decreased physical performance.

 

NAD+ reverses the hallmarks of aging

Research has identified 12 key processes that occur inside the cell that cause the aging process, these are termed the ‘Hallmarks of Aging’. Since their identification, focus has now shifted on finding ways to target these hallmarks to slow and even reverse the aging process.

Some key points to remember when looking at the science of aging are:

  • Cells are like tiny factories filled with machinery, they are constantly making things, repairing things, recycling things and communicating with each other.
  • Lots of energy and effort is put into maintenance and repair to keep all the cellular machinery running properly and allow the cells to function at their best.
  • Cells contain energy powerhouses called mitochondria which provide the cellular energy needed to power all these processes and the DNA is the instruction manual, guiding how the factory operates.
  • Cells also have epigenetics which switches on and off different parts of the DNA to control how the cell functions to align with the requirements and environment of the cell.

 

NAD+ has become an area of interest because it is one of the only molecules that has been found to improve all 12 hallmarks of aging and keep the cellular ‘factories’ working optimally.  Nuchido TIME+ is clinically proven to increase levels of NAD+ and sirtuins.

The table below gives an overview of how NAD+ and sirtuin activity work together to target the Hallmarks of Aging.

Genomic Instability

Adequate NAD+ availability is critical to drive DNA repair enzymes and pathways such as PARP1, SIRT1, and SIRT6. Conditions associated with premature aging have reduced DNA repair capabilities and reduced NAD+ levels.

Cellular Senescence

Low NAD+ promotes senescence in whilst restoration of NAD+ reduces the burden of senescent cells.

Epigenetic Alterations

NAD+-dependent sirtuins are critical for youthful epigenetic regulation. Reduced NAD+ means sirtuins cannot perform this critical role, contributing to altered gene expression during aging.

Mitochondrial Dysfunction

Adequate NAD+ is critical for optimal mitochondrial function Via its interaction with sirtuins, NAD+ regulates; Mitochondrial biogenesis (production of new mitochondria) Mitophagy (the recycling of damaged mitochondria) Stress resistance and repair pathways

Telomere Attrition

NAD+ restoration is found to alleviate telomere dysfunction

Altered Cellular Communication

Low NAD+ promotes age-related inflammation, which impairs cellular communication.

Loss of Proteostasis

NAD+ is required for SIRT1-mediated activation of autophagy to clear damaged cellular proteins.

Deregulated nutrient sensing

NAD+ levels are critical to sense the energetic status of the cell for adaptation to energy stress. NAD+ decline impairs nutrient sensing pathways AMPK, Sirtuins and PGC-1α.

Stem cell exhaustion

NAD+ restoration leads to stem cell rejuvenation.

Loss of Autophagy

NAD+ and SIRT1 directly activate autophagy and mitophagy (the recycling of damaged mitochondria) and activate AMPK to further stimulate cellular repair and longevity.

Chronic Inflammation

NAD+ and SIRT1 activate anti-inflammatory pathways, to ensure that inflammation is only activated when needed. NAD+ decline contributes to loss of cellular repair which promotes cells to become senescent, further increasing chronic inflammation.

Gut Dysbiosis

NAD+ supports energy production within microbes and is required for enzymes that support microbial survival and reproduction. NAD+ improves gut composition by increasing levels of beneficial bacteria.

 

Biological age tests measure your rate of aging

The research into the aging process has led to the concept of biological aging. This reflects how well you are aging at the cellular level, how your cells are functioning and how much damage they have accumulated. Biological age can differ greatly from chronological age, (which is simply the number of years since your birth) because the rate of cellular aging isn’t that closely linked to chronological age.

For example, someone could be chronologically 40 years old but they could have a biological age of 55 indicting that cellular repair has been turned down and they are aging at an accelerated rate. The opposite can also be true with people having a biological age younger than their chronological age.

However, unlike your chronological age, biological age is flexible and can be reversed.

 

Nuchido TIME+ reverses biological age

So, how do we know that Nuchido TIME+ truly altered the aging process? Well, we measured it.

Many consumer-friendly biological age tests are now available and we partnered with GlycanAge during our clinical trial to measure the impact of Nuchido TIME+ on the biological age of our participants. After just 28 days Nuchido TIME+ reversed participants biological age by an average of 1.26 years. Many participants had even greater reductions, which is very exciting in such a short time frame. This makes sense given the role of NAD+ in powering cellular repair and rejuvenation.

 

There are many products on the market that claim to ‘reverse aging’ but many of these have no clinical evidence to back-up these claims.  Nuchido TIME+ goes beyond the surface, addressing the root causes of aging at the cellular level, to give measurable benefits to cellular health and function.