How Nuchido TIME+ reverses aging

When you think of anti-aging products you may think of face creams and collagen supplements. However, these products merely work to fix the consequences of aging, and fail to address the reasons why aging is occurring in the first place.

NAD+ supplements have emerged as a new approach to healthy aging though, by restoring your cellular health. This new generation of products, supported by scientific evidence, goes beyond the surface to address the root causes of aging at the cellular level.

Why Do NAD+ and Sirtuins Work Together Effectively?

NAD+ and sirtuins work together to promote cellular health. NAD+ is an anti-aging molecule naturally found in every cell, while the sirtuins are a family of seven proteins – often referred to as longevity proteins – that perform critical cellular functions.

Among its many benefits, NAD+ acts as a fuel to drive the activity of the sirtuins. Without NAD+ being present, these longevity proteins cannot function. This means that as NAD+ levels decline during aging, the same will happen to sirtuin activity.

The key functions of NAD+ and sirtuins include:

Cellular repair and rejuvenation
Cellular energy production

Therefore, when NAD+ and sirtuin activity decline, cellular damage accumulates in cells and tissues, preventing them from functioning properly, driving the aging process. This is felt as fatigue, brain fog, sleep disruptions, loss of skin elasticity and decreased physical performance.

How Can NAD+ Reverse the Hallmarks of Aging?

Research has identified 12 key processes that occur inside the cell that cause the aging process; these are termed the ‘Hallmarks of Aging’. Since their identification, focus has now shifted to finding ways to target these hallmarks to slow and even reverse the aging process.

Some key points to remember when looking at the science of aging are:

Cells are like tiny factories filled with machinery. They are constantly making things, repairing things, recycling things and communicating with each other.
Lots of energy and effort is put into maintenance and repair to keep all the cellular machinery running properly and allow the cells to function at their best.
Cells contain energy powerhouses called mitochondria, which provide the cellular energy needed to power all these processes. The DNA is then the instruction manual, guiding how the factory operates.
Cells also have epigenetics, which switches on and off different parts of the DNA to control how the cell functions to align with the requirements and environment of the cell.

Research has identified 12 key processes that occur inside the cell that cause the aging process., These are termed the “‘Hallmarks of Aging”’.

Since their identification, focus has now shifted to finding ways to target these hallmarks to slow and even reverse the aging process.

NAD+ has become an area of interest with this topic in mind. This is because it is one of the only molecules found to improve all 12 hallmarks of aging and keep the cellular ‘factories’ working optimally.

The table below gives an overview of how NAD+ and sirtuin activity work together to target the Hallmarks of Aging.

Genomic Instability	Adequate NAD+ availability is critical to drive DNA repair enzymes and pathways such as PARP1, SIRT1, and SIRT6. Conditions associated with premature aging have reduced DNA repair capabilities and reduced NAD+ levels.
Cellular Senescence	Low NAD+ promotes senescence, while restoration of NAD+ reduces the burden of senescent cells.
Epigenetic Alterations	NAD+-dependent sirtuins are critical for youthful epigenetic regulation. Reduced NAD+ means sirtuins cannot perform this critical role, contributing to altered gene expression during aging.
Mitochondrial Dysfunction	Adequate NAD+ is critical for optimal mitochondrial function. Via its interaction with sirtuins, NAD+ regulates: Mitochondrial biogenesis (production of new mitochondria), Mitophagy (the recycling of damaged mitochondria), stress resistance and repair pathways.
Telomere Attrition	NAD+ restoration is found to alleviate telomere dysfunction.
Altered Cellular Communication	Low NAD+ promotes age-related inflammation, which impairs cellular communication.
Loss of Proteostasis	NAD+ is required for SIRT1-mediated activation of autophagy to clear damaged cellular proteins.
Deregulated nutrient sensing	NAD+ levels are critical to sense the energetic status of the cell for adaptation to energy stress. NAD+ decline impairs nutrient-sensing pathways AMPK, Sirtuins and PGC-1α.
Stem cell exhaustion	NAD+ restoration leads to stem cell rejuvenation.
Loss of Autophagy	NAD+ and SIRT1 directly activate autophagy and mitophagy (the recycling of damaged mitochondria) and activate AMPK to further stimulate cellular repair and longevity.
Chronic Inflammation	NAD+ and SIRT1 activate anti-inflammatory pathways, to ensure that inflammation is only activated when needed. NAD+ decline contributes to loss of cellular repair, which promotes cells to become senescent, further increasing chronic inflammation.
Gut Dysbiosis	NAD+ supports energy production within microbes and is required for enzymes that support microbial survival and reproduction. NAD+ improves gut composition by increasing levels of beneficial bacteria.

Biological Age Tests Measure Your Rate of Aging

Research into the aging process has led to the concept of biological aging. This reflects how well you are aging at the cellular level, how your cells are functioning and how much damage they have accumulated. Biological age can differ greatly from chronological age (which is simply the number of years since your birth) because the rate of cellular aging isn’t that closely linked to chronological age.

For example, someone could be chronologically 40 years old but could have a biological age of 55. This indicates that cellular repair has been turned down, and they are aging at an accelerated rate. The opposite can also be true, with people having a biological age younger than their chronological age.

However, unlike your chronological age, biological age is flexible and can be reversed.

How Nuchido TIME+ Reverses Biological Age

The Nuchido TIME+ formulation is designed and clinically proven to boost cellular levels of NAD+ and sirtuins.

Wondering just how we know that Nuchido TIME+ truly altered the aging process? Well, we measured it.

We partnered with GlycanAge during our clinical trial to measure the impact of Nuchido TIME+ on the biological age of our participants. After just 28 days, Nuchido TIME+ reversed participants' biological age by an average of 1.26 years. Many participants had even greater reductions, which is very exciting in such a short time frame. This makes sense given the role of NAD+ in powering cellular repair and rejuvenation.

There are many products on the market that claim to ‘reverse aging’, but many of these have no clinical evidence to back up these claims. Nuchido TIME+ goes beyond the surface, though. This anti-aging supplement addresses the root causes of aging at the cellular level to give measurable benefits to cellular health and function.

Buy Nuchido TIME+ supplements online today, as either a one-time purchase or through a cost-saving subscription plan that can be cancelled at any time.

Have more questions about Nuchido TIME+ before you complete your order of these anti-aging supplements? We will either have the answer to your query on our comprehensive FAQs page or we encourage you to direct your specific questions to our excellent customer support team.