Nuchido TIME+ contains a combination of ingredients that are clinically proven to fix the root causes of NAD+ decline. This patented whole-system approach to boosting NAD+ is unique and goes beyond what other products like NR/NMN, NAD+ injections or IV infusions deliver.

usp image 1 Patented Formulation
usp image 2 Clinically proven benefits
usp image 3 Vegan and gluten free
usp image 4 Ingredients your cells can absorb
usp image 5 No additives or bulking agents
usp image 6 Restores natural NAD+ production
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NICOTINAMIDE

FUNCTION: Raw material for NAD+ production
  • NAD+ cannot be obtained from our diet. It must be made within our cells.
  • Nicotinamide (a form of niacin) is one of the raw materials that the body uses to make NAD+. It is sometimes referred to as an “NAD+ precursor”.
  • Nuchido TIME+ contains nicotinamide to give our cells an adequate supply of the raw material they need to manufacture NAD+.
  • Some forms of niacin (such as nicotinic acid) cause a “flushing” reaction. Nicotinamide does not cause this reaction.
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QUERCETIN & RUTIN

SOURCE: Sophora Japonica Flowers
FUNCTION: Increase NAD+ production
  • The dried flowers of the Sophora Japonica tree are made up of powerful flavonoids including quercetin, rutin and troxrutin.
  • These flavonoids were selected for our formulation based on their ability to activate the NAD+ salvage pathway enzyme NAMPT.
  • This enzyme is critical to the production of NAD+ but declines with age. These compounds are proven to increase NAMPT enzyme levels and improve NAD+ production.
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ALPHA LIPOIC ACID

SOURCE: GeroNova's Bio-Enhanced® R-Lipoic Acid
FUNCTION: Increase NAD+ production
  • ALA helps to boost NAD+ levels in two ways:
  • Firstly, it activates a cellular energy sensor (called AMPK) which switches on NAD+ production in the cell (this is the same pathway that is responsible for the beneficial effects of exercise and fasting).
  • Secondly, ALA activates pathways that promote the conversion of NADH to NAD+.
  • Most ALA found in supplements is a 50:50 mix of the R-(natural) and S-(synthetic) form. However, only the R-ALA form can be utilized by our cells.
  • Nuchido TIME+ contains GeroNova's Bio-Enhanced® pure R-Lipoic Acid which has been shown to provide superior bioavailability, stability, and potency compared to other forms of ALA.
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EGCG

SOURCE: Green tea extract
FUNCTION: Increase NAD+ production
  • Green tea is one of the most beneficial beverages on the planet and much of this is credited to a powerful compound it contains called epigallocatechin-3-gallate (EGCG).
  • In Nuchido TIME+ EGCG is used to inhibit a cellular enzyme called NNMT. This enzyme increases with age, preventing NAD+ recycling in our cells.
  • Inhibiting NNMT is known to increase NAD+ levels.
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APIGENIN

SOURCE: Parsley leaf extract
FUNCTION: Reduce NAD+ demand
  • Parsley contains multiple bioactive compounds, and is one of the best natural sources of apigenin. 
  • One of the main reasons cellular NAD+ declines as you age, is due to increased levels of an inflammatory protein called CD38. CD38 uses up high levels of your cellular NAD+.
  • Apigenin is scientifically proven to inhibit CD38, which means that NAD+ levels are not depleted and can be directed towards beneficial repair pathways in your cells.
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    SUPPORTIVE INGREDIENTS

    These ingredients are included to support overall wellbeing and enhance absorption of the other ingredients in Nuchido TIME+
    VITAMIN C

    Vitamin C supports many cellular protection and repair pathways. In fact, people who take regular Vitamin C are found to live long and healthy lives.

    ZINC

    Zinc is an essential micronutrient that plays a vital role in normal immune function. As we age, there is a progressive decline in our immune system’s resilience. Supplementation with zinc has been found to help slow this impairment.

    BLACK PEPPER

    Black pepper includes piperine, a dietary ingredient that improves absorption of the other important ingredients in our formula. Piperine helps to increase the uptake of nutrients from the small intestine, allowing them to enter the blood and access the rest of the body. Piperine is also known to increase metabolism by activating thermogenesis, a process that breaks down fat cells.

    THE TIMES+

    Read our blog to learn more about our unique whole-systems approach and other NAD+ insights

    Why Nuchido TIME+ doesn’t contain NMN or NR

    Why Nuchido TIME+ doesn’t contain NMN or NR

    If you’ve heard of NAD+ supplements then you’ve probably heard of NAD+ precursor supplements such as NMN and NR. One of the most common questions we receive at Nuchido is...