Precursors Boost NAD+, But, Not Enough

When your NAD+ levels are high it makes you feel great and boosts the energy you need to stay strong and enjoy life.

Until recently the only way to boost NAD+ levels with scientific credibility was to supplement with precursors like NR and NMN. 

Precursor supplements do actually increase cellular NAD+ levels, which is good, but the boost they give is only modest (40-60%) and hits a premature limit. Precursors like NR and NMN struggle to lift NAD+ back to the high levels young people enjoy, which is what older individuals need for effective cell rejuvenation.

This limitation of precursors has been revealed by scientific data showing that simply increasing the dose of precursor does not mean the body makes more NAD+ (Trammell et al. 2016). To explain why this happens we need to understand the importance of the cellular NAD+ Salvage Pathway and why its gradual failure over time really matters.


The NAD+ salvage pathway

Our cells can make nearly all of the NAD+ they need by recycling 'waste' nicotinamide. When cells consume NAD+ it gets converted into nicotinamide by the NAD+ Salvage Pathway, which then recycles 'waste' nicotinamide back into fresh NAD+. When the nicotinamide recycling process works with youthful efficiency it makes nearly all of the NAD+ we need and very little precursor material is required to 'top up' cellular NAD+ production.

But older cells don’t have the recycling capacity they once did, which means over time our levels of NAD+ drift downwards as cells struggle to recycle 'waste' nicotinamide back into NAD+.

Topping up NAD+ levels with a precursor like NR or NMN therefore seems like a good idea, but there's a problem. The modest NAD+ boost provided by precursors is soon used up by the cell and turned into waste nicotinamide. In young cells this would be recycled into fresh NAD+ but in old cells they don't have the capacity to do this. Instead the nicotinamide is methylated and excreted from the cell as waste.

This means using high dose precursor supplementation to boost NAD+ in mature cells is like trying to boost production in an old car factory. Trucking more raw steel through the factory gate will never increase the output of new cars when the machines are worn out, the production line is under staffed and most of the raw material is, quite literally, ‘leaking’ back out.

To fix this problem Nuchido TIME+ has pioneered a new approach to boosting NAD+ that addresses the underlying problems that cause age-related NAD+ decline, meaning that it doesn't need NR or NMN precursors to achieve compelling results.



Trammell SA, Schmidt MS, Weidemann BJ, Redpath P, Jaksch F, Dellinger RW, Li Z, Abel ED, Migaud ME, Brenner C. Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun. 2016 Oct 10;7:12948. PubMed PMID: 27721479